Introduction
If you suffer from seasonal allergies, hay fever, or chronic hives, you have likely heard of Xyzal (Levocetirizine) and Allegra (Fexofenadine). These two popular second generation antihistamines provide 24-hour allergy relief with fewer drowsiness effects than older antihistamines like Benadryl. But which one is the better choice?
This detailed comparison will cover: ✔️ Effectiveness and onset of action
✔️ Side effects
✔️ Dosage and safety
✔️ Cost and availability
✔️ Best option for specific allergy types
By the end, you shall know whether Xyzal or Allegra is the best fit for you!
How Do Xyzal and Allegra Work?
Both Xyzal and Allegra work by blocking histamine receptors in the body. Histamine is responsible for causing allergy symptoms such as: ✔️ Sneezing
✔️ Runny or stuffy nose
✔️ Itchy, watery eyes
✔️ Hives and skin irritation
By preventing histamine from binding to receptors, these medications provide fast long lasting relief from allergic reactions.
Effectiveness: Which Works Faster?
✅ Xyzal: Works within 30 to 60 minutes and provides relief for 24 hours.
✅ Allegra: Begins working in about 1 hour and lasts 24 hours.
💡 Key Difference: Xyzal is slightly faster than Allegra in onset of action.
Dosage and Usage
| Medication | Adults & Kids (12+ years) | Children (6-11 years) | Children (6 months – 5 years) |
|---|---|---|---|
| Xyzal | 5 mg once daily | 2.5 mg once daily | 1.25 mg once daily |
| Allegra | 180 mg once daily OR 60 mg twice daily | 30 mg twice daily | 15 mg twice daily |
💡 Key Difference: Allegra is available in multiple dosing options (once or twice daily), while Xyzal is typically taken once daily.
Side Effects: Which is Safer?
Both medications are well tolerated but some people may experience mild side effects.
Common Side Effects
| Side Effect | Xyzal | Allegra |
| Drowsiness | ✅ Possible | ❌ Less Likely |
| Dry Mouth | ✅ Common | ✅ Less Common |
| Fatigue | ✅ Possible | ❌ Less Likely |
| Headache | ✅ Possible | ✅ Possible |
💡 Allegra is considered the least sedating antihistamine among second generation options making it ideal for daytime use.
Serious Side Effects (Rare)
🚨 Severe dizziness
🚨 Rapid heartbeat
🚨 Swelling of the face or throat
🚨 Difficulty breathing
⚠️ Consult a doctor if you experience any severe side effects!
Which One is Better for Different Allergy Types?
✔️ For Seasonal Allergies (Hay Fever): Both Xyzal and Allegra are effective but Allegra is preferred for daytime use since it causes less drowsiness. ✔️ For Chronic Hives (Urticaria): Xyzal is often more effective for chronic urticaria, providing better relief for itchy skin conditions. ✔️ For Indoor Allergies (Dust, Pet Dander): Xyzal may have a slight edge due to its longer lasting potency. ✔️ For Allergy Related Sleep Issues: Xyzal can help those who experience nighttime allergies, since it may cause mild drowsiness.
💡 Best Choice: Xyzal for nighttime allergy relief and chronic hives Allegra for daytime use and seasonal allergies.
Cost and Availability
| Medication | Brand Name Price (30 Tablets) | Generic Price |
| Xyzal | ~$25-30 | $12-18 |
| Allegra | ~$20-25 | $10-15 |
💡 Allegra is slightly more affordable than Xyzal making it a more budget friendly option.
Can You Take Xyzal and Allegra Together?
🚫 No! Taking both medications together is not recommended as it increases the risk of side effects like drowsiness and dry mouth.
Final Verdict: Which One Should You Choose?
✅ Choose Xyzal if:
- You need a stronger antihistamine for chronic hives or severe allergies.
- You don’t mind mild drowsiness (or prefer it for nighttime relief).
- You want a lower dosage but strong effect.
✅ Choose Allegra if:
- You need a non drowsy antihistamine for daytime allergy relief.
- You prefer a medication with fewer side effects.
- You want more dosage flexibility (once or twice daily options).
📌 Bottom Line: If you need a stronger long lasting allergy medication go with Xyzal. If you need a non drowsy option for daytime allergies pick Allegra!
FAQs
1. Is Xyzal stronger than Allegra?
Yes Xyzal is generally considered more potent and may be better for chronic hives or severe allergies.
2. Which is better for pet allergies?
Both work well but Xyzal may provide longer lasting relief.
3. Can I take Allegra at night?
Yes but since it is non drowsy it may not help if you have nighttime allergy symptoms.
4. Can I drink alcohol while taking these medications?
It is best to avoid alcohol as it may increase drowsiness with Xyzal.
5. Is Xyzal worth the higher price?
If you need stronger long lasting allergy relief then yes.
Final Thoughts
Both Xyzal and Allegra are excellent antihistamines but your choice depends on your specific needs. ✔️ Pick Xyzal for stronger longer lasting allergy relief and chronic hives.
✔️ Pick Allegra if you want a non drowsy daytime friendly antihistamine.
💡 Tip: If drowsiness is a concern Allegra is your best bet!